GHB/GBL

It is always safest not to take unknown or illicit drugs at all.  However, if you do decide to use G, be informed on the risks involved and how to be as safe as possible.

What is it?

  • G is the name given to the drugs GHB (gamma hydroxybutyrate) and GBL (gamma butyrolactone).
  • Other names include G, Gina, Liquid E and Liquid ecstasy.
  • GHB is an odourless, oily liquid, with a slightly salty taste, usually sold in small bottles or capsules.  The effects usually occur within 15-20 minutes and last up to 3-4 hours.
  • GBL is a liquid with a chemical smell and taste. GBL is a precursor to GHB, which means that it is converted to GHB inside your body after swallowing.  It has a faster onset of action than GHB, and is often more potent – so a smaller dose is required to have the same effect.
  • G is usually swallowed in its liquid form, often mixed with water or a soft drink. Never mix G with alcohol as these 2 substances interact and can lead to death.  Less often it is snorted or inhaled.  Injecting G is dangerous.

What does it do?

  • Both GHB and GBL are depressant drugs which can produce a high with small doses, and cause sedation with only slightly higher doses.  People report that G makes them feel euphoric, with a loss of inhibitions, increased confidence, and a higher sex drive.

What are the risks?

  • It is easy to overdose on G, as there is not much difference (less than one millilitre) between a dose that gets a person high, and a dose that has them “going under” – becoming unconscious and unresponsive.
  • Avoid mixing G with alcohol. This can increase the risk of going under, and delay the time it takes for G to take effect – interfering with safe dosing intervals.
  • A number of deaths have been caused by G. Death can result from overdose, or severe withdrawal syndrome.
  • Using G with other depressant drugs, such as alcohol, benzodiazepines and ketamine can increase the risk of going under and stopping breathing. In some cases, people might be hospitalised after using G.
  • G is addictive and dependence can develop quickly. Dependence mean people will develop withdrawal symptoms on stopping use, which can be severe and life-threatening.
  • The sedative properties of G can leave a person incoherent or comatose. People around you may take advantage of this to have sex with you without your consent.

Is G illegal?

  • GHB and GBL are both Class B drugs – but GBL is available for legitimate use in industry. However, if someone supplies or possesses them knowing or believing that they will be swallowed and ingested, they are committing an offence.
  • Possession of G can get you up to two years in prison and/or an unlimited fine.
  • Supplying someone else, even your friends, can get you fourteen years in jail and/or an unlimited fine.

Going under – what to do:

  • If you see someone going under or collapsing while on G:
  • Place them in the recovery position to prevent them from choking.
  • Call an ambulance. Dial 999.
  • Don’t take any more drugs.
  • Stay with the person until the ambulance arrives.
  • Tell the medics what the person may have taken. Be truthful.  If available, give the medics the bottle or what is left of the G.

Withdrawal:

  • The onset of withdrawal can begin 1-2 hours after the last dose and can progress rapidly. Withdrawal can last up to 12 days.
  • Mild withdrawal symptoms include: anxiety; tremors; insomnia; vomiting and high blood pressure.
  • More severe symptoms include severe anxiety; paranoia and psychosis; confusion; delirium and hallucinations. Seizure and death may occur.
  • If you have taken G for more than 7 days in a row, DO NOT attempt to stop by yourself. Withdrawal should be a tapered process with medical supervision. See drug services below, or attend A&E.

Tips for safer use:

  • Prepare your own G. Always premeasure G carefully using a syringe or pipette that is measured in millilitres. Never swig G from the bottle.
  • Always dose yourself so you are in control of what you are taking and how much – don’t let others do it for you.A typical dose varies between 0.5ml to 1,5ml, although everyone reacts differently. Even a very little dose, below 1 ml, could lead to an overdose without any warning.
  • Always use as low a dose as possible, and wait until the effects are felt, because the strength of G can vary. Wait at least 3 hours before taking a second dose.
  • Due to the variable street quality of the drug and chemical differences between GHB and GBL, be cautious not to mix different types of G. If the drug comes from various sources, less frequent dosing is necessary to avoid accidental overdose.
  • Because G can affect your memory, always record the time you have taken the dose and keep it in a visible place.
  • Take G orally. Do not snort or inject.
  • Avoid mixing G with alcohol or other depressant drugs.
  • If you can, use food colouring to identify the G, so you won’t accidentally mix it with other drinks or water- this will reduce the possibility of overdose.
  • Store G safely, out of reach of children and other adults.

Gamma-butyrolactone (GBL) is used in cleaning solvents and similar industrial products. It is also used as a precursor to make the illicit substance gamma-aminobutyric acid (GHB) or is ingested to produce euphoric effects. GBL can cause many short-term and long-term risks and can lead to dependence and addiction.

Key takeaways:

  • Gamma-butyrolactone (GBL) is a chemical that is used licitly in industrial products and illicitly as a drug of abuse or date rape drug.
  • The effects of GBL can include sedation, euphoria, reduced inhibition, increased sex drive, loss of consciousness, and nausea.
  • GBL use can lead to dependence and addiction, which may require professional advice and treatment.
a close up photo of a hand dropping GBL on a drink at a club

What is gamma-butyrolactone (GBL)?

Gamma-butyrolactone (GBL) is a chemical that is used in industrial products and as an alternative or precursor chemical to the illicit substance gamma-hydroxybutyric acid (GHB). 

GBL is now becoming increasingly used as a substance of abuse. It converts to GHB in the body rapidly after ingestion and therefore, causes very similar effects to GHB.  GBL is often sold as a liquid, which is ingested when used as a drug of abuse in order to create euphoric effects. 

GHB occurs naturally in the body in small concentrations and impacts the neurotransmitter gamma-aminobutyric acid (GABA). It causes similar central nervous system (CNS) depressant effects to other GABA-related substances, including benzodiazepines, although its mechanism of action differs. 

Uses and effects of GBL

GBL is used as an industrial solvent and included in various products such as paint removers, cleaning products, and engine degreasers. This means it can be purchased legally for legitimate purposes. However, it can also be used as a precursor chemical to create GHB or sold as an illicit substance for recreational use. 

Recreational use and sought-after effects

In the 1990s, recreational GHB use increased, with many using it as a party drug. At this time, it also became more widely used in sexual assaults. In recent years, GBL abuse has become common. GBL is a popular alternative as its effects emerge quicker than GHB and last for longer. Additionally, GBL is easier and cheaper to obtain than GHB. 

Often, people who abuse GBL or GHB do so for its euphoric and sedative effects. It is commonly used as a substitute for alcohol at ‘raves’ or parties, and it reportedly enhances sexual pleasure

Use of GBL in sexual assaults

There are reports of GBL or GHB being used to spike a person’s drink to facilitate sexual assault. As is the case with many ‘date rape drugs’, GBL and GHB can cause the individual to be unresponsive or unconscious. 

A systematic review of reported sexual assaults found that GHB had been detected in 0.2-4.4% of cases. 

Health risks and side effects

The effects and risks of GBL can depend on the frequency and amount of use, individual age, weight, and health, and the use of additional substances. GBL causes CNS depressant effects, which can lead to effects such as: 

  • Sedation
  • Drowsiness
  • Nausea
  • Distorted vision
  • Confusion
  • Impaired coordination
  • Headaches

Long-term effects of GBL use can include: 

  • Dependence and addiction
  • Heart problems
  • Psychotic symptoms
  • Breathing issues
  • Anxiety
  • Liver and kidney damage

Overdose

High doses of GBL can cause overdose, which can be severe and even fatal. Signs of GBL overdose can include: 

  • Loss of consciousness
  • Seizure
  • Reduced heart rate and breathing rate
  • Decreased body temperature
  • Severe slowing or stopping of breathing
  • Nausea and vomiting
  • Coma

In the event of GBL overdose, particularly if the person is unconscious or not breathing, call 911 immediately. Urgent medical attention is required. There is no antidote for GBL overdose, but treatment can be provided to help manage severe symptoms. 

Interactions

GBL is likely to interact with other medications or substances if consumed concurrently. For example: 

  • Combining GBL with other CNS depressants, such as alcohol, benzodiazepines, or opioids, could increase the risk of respiratory depression and loss of consciousness.
  • Combining GBL with stimulants, such as methamphetamine or ecstasy, could increase the risk of heart problems.

GBL is not intended for human consumption. It is included as a List 1 chemical on the Controlled Substances Act (CSA), as it is a precursor to the Schedule I controlled substance GHB. As a List 1 chemical, people who buy or sell GBL must be registered with the DEA to monitor for legitimate business use of GBL. 

If GBL is intended for consumption, it can be treated as a Schedule I controlled substance. Schedule I substances have no recognized medical purpose and a high potential for abuse, addiction, and harm.  Sodium oxybate (Xyrem) is a pharmaceutical GHB preparation, which is classified as a Schedule III controlled substance and can be used to treat narcolepsy. 

Can GBL be detected in your body?

GBL cannot be detected in the system, but can be detected as GHB, as it converts quickly after ingestion. GHB has a short half-life of 30-50 minutes, so it typically leaves the body entirely within 3-4 hours. 

This can mean that there is only a small window in which it can be detected in the system. Urine tests can be used to detect GHB within a window of 3-10 hours. Also, only 1-5% of the original dose is eliminated in urine, meaning that it can go undetected. 

Recognizing GBL misuse and addiction

People may display signs that they are misusing GBL and developing dependence and addiction. Signs of GBL addiction can include:

  • Increasing issues with functioning at work, school, and socializing due to GBL use
  • Decline in self-care
  • Neglecting responsibilities and commitments to use GBL
  • Using increasing amounts of GBL or with increasing regularity
  • Impacted physical and psychological well-being
  • Financial issues

GBL withdrawal

People who abuse GBL may develop dependence after prolonged or excessive use. When GBL use is stopped, withdrawal symptoms can occur, including: 

  • Increases in heart rate and blood pressure
  • Insomnia
  • Depression
  • Anxiety
  • Shaking
  • Psychotic symptoms, including paranoia and hallucinations
  • Seizures
  • Heart problems

Withdrawal symptoms can emerge within 1-6 hours after the last dose and typically last up to two weeks. Abruptly stopping chronic GBL use can increase the severity of withdrawal symptoms. Professional advice and support may be necessary when stopping GBL use. 

Treatment options for GBL dependence

People who are dependent on or addicted to GBL may benefit from professional advice and treatment. As withdrawal from GBL can be severe and potentially harmful, it could be necessary to utilize supported withdrawal and detox services Following withdrawal, treatments to help people in GBL addiction recovery can include rehabilitation services, psychotherapy, behavioral therapy, or medications.

A primary care physician can refer individuals to specialist services to begin treatment. The Recovered Directory can help with finding local rehab centers.

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